3,7-Dimethylguanine, a new purine from a Philippine sponge Zyzzya fuliginosa.
نویسندگان
چکیده
A new purine 3,7-dimethylguanine (1) has been isolated from the marine sponge Zyzzya fuliginosa, along with the known metabolites, makaluvamines A, C, K (2--4), 4-hydroxyphenylacetic acid (5), methyl ester of 4-hydroxyphenylacetic acid (6), 4-hydroxyphenethyl alcohol (7), L-phenylalanine (8) and L-tryptophan (9). The structure of 3,7-dimethylguanine (1) was elucidated by analysis of 1D and 2D (one- and two-dimensional) NMR [HMQC (heteronuclear multiple quantum coherence), gHMBC (heteronuclear multiple bond connectivity), 1H-15N gHMBC] data, mass spectroscopy data, and by comparison with 3,7-dimethylisoguanine (10).
منابع مشابه
Another Look at Pyrroloiminoquinone Alkaloids—Perspectives on Their Therapeutic Potential from Known Structures and Semisynthetic Analogues
This study began with the goal of identifying constituents from Zyzzya fuliginosa extracts that showed selectivity in our primary cytotoxicity screen against the PANC-1 tumor cell line. During the course of this project, which focused on six Z. fuliginosa samples collected from various regions of the Indo-Pacific, known compounds were obtained consisting of nine makaluvamine and three damirone ...
متن کاملAntimalarial activity of pyrroloiminoquinones from the Australian marine sponge Zyzzya sp.
A new bispyrroloiminoquinone alkaloid, tsitsikammamine C (1), displayed potent in vitro antimalarial activity with IC(50) values of 13 and 18 nM against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum, respectively. Tsitsikammamine C (1) displayed selectivity indices of >200 against HEK293 cells and inhibited both ring and trophozoite stages of the malaria para...
متن کاملPatterns of excretion of methylated purines in hepatocellular carcinoma.
The quantities of total and free guanine, adenine, hypoxanthine, and six of their methylated derivatives and of 6-succinoaminopurine have been measured in urine speci mens from cases of hepatocellular carcinoma and cirrhosis of the liver, and from normal subjects. Total base was defined as the sum of the free purine plus the increment released by means of acid hydrolysis. Analyses were per form...
متن کاملICANCER ESEARCH34,986990,May1974] Patterns of Excretion of Methylated Purines in Hepatocellular Carcinoma
The quantities of total and free guanine, adenine, hypoxanthine, and six of their methylated derivatives and of 6-succinoaminopurine have been measured in urine speci mens from cases of hepatocellular carcinoma and cirrhosis of the liver, and from normal subjects. Total base was defined as the sum of the free purine plus the increment released by means of acid hydrolysis. Analyses were per form...
متن کاملCytotoxic bromoindole derivatives and terpenes from the Philippine marine sponge Smenospongia sp.
A detailed chemical analysis of a Philippine marine sponge Smenospongia sp. has been performed. This study yielded four new metabolites, 5-bromo-L-tryptophan (1), 5-bromoabrine (2), 5,6-dibromoabrine (3) and 5-bromoindole-3-acetic acid (4). The pyrroloiminoquinone alkaloid, makaluvamine O (5) as well as 5,6-dibromotryptamine (6), aureol (7) and furospinulosin 1 (8) were also isolated. Although ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 49 12 شماره
صفحات -
تاریخ انتشار 2001